Micropatterned methacrylate polymers direct spiral ganglion neurite and Schwann cell growth
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چکیده
منابع مشابه
Micropatterned Schwann cell-seeded biodegradable polymer substrates significantly enhance neurite alignment and outgrowth.
Biomimetic strategies were employed to promote directional outgrowth of neurites in vitro by using a synergistic combination of physical, chemical, and cellular cues. Compression molded and solvent cast biodegradable polymer substrates made of poly(D,L-lactic acid) were micropatterned to form grooves on the substrate surfaces. Laminin was localized in the grooves, and rat sciatic Schwann cells ...
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The transplantation of Schwann cells (SCs) could successfully promote axonal regeneration. This is likely to attribute to the adhesion molecules expression and growth factors secretion of SCs. But which factor(s) play a key role has not been precisely studied. In this study, an outgrowth assay using dorsal root ganglia (DRG) neuron-SC co-culture system in vitro was performed. Co-culture of SCs ...
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During both development and regeneration of the nervous system, neurons display complex growth dynamics, and several neurites compete to become the neuron's single axon. Numerous mathematical and biophysical models have been proposed to explain this competition, which remain experimentally unverified. Large-scale, precise, and repeatable measurements of neurite dynamics have been difficult to p...
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During both development and regeneration of the nervous system, neurons display complex growth dynamics, and several neurites compete to become the neuron’s single axon. Numerous mathematical and biophysical models have been proposed to explain this competition, which remain experimentally unverified. Large-scale, precise, and repeatable measurements of neurite dynamics have been difficult to p...
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Strategies of Schwann cell (SC) transplantation to regenerate the peripheral nerve injury involves many limitations. Stem cells can be used as alternative cell sources for differentiation into SCs. Given the high potential of neural crest-derived stem cells for the generation of multiple cell lineages, in this research, we considered whether olfactory ecto-mesenchymal stem cells (OE-MSCs) derive...
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ژورنال
عنوان ژورنال: Hearing Research
سال: 2011
ISSN: 0378-5955
DOI: 10.1016/j.heares.2011.05.004